Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population.

ABSTRACT:

Background

Type 2 diabetes (T2D) susceptibility is influenced by genetic and lifestyle factors. To date, the majority of genetic studies of T2D have been in populations of European and Asian descent. The focus of this study is on genetic variations underlying T2D in Qataris, a population with one of the highest incidences of T2D worldwide.

Results

Illumina HiSeq exome sequencing was performed on 864 Qatari subjects (574 T2D cases, 290 controls). Sequence kernel association test (SKAT) gene-based analysis identified an association for low frequency potentially deleterious variants in 6 genes. However, these findings were not replicated by SKAT analysis in an independent cohort of 12,699 exomes, primarly due to the absence of low frequency potentially deleterious variants in 5

SUBMITTER: O'Beirne SL 

PROVIDER: S-EPMC6136697 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature