Immune effectors responsible for the elimination of hyperploid cancer cells.

ABSTRACT: The immune system avoids oncogenesis and slows down tumor progression through a mechanism called immunosurveillance. Nevertheless, some malignant cells manage to escape from immune control and form clinically detectable tumors. Tetraploidy, which consists in the intrinsically unstable duplication of the genome, is considered as a (pre)-cancerous event that can result in aneuploidy and contribute to oncogenesis. We previously described the fact that tetraploid cells can be eliminated by the immune system. Here, we investigate the role of different innate and acquired immune effectors by inoculating hyperploid cancer cells into wild type or mice bearing different immunodeficient genotypes (Cd1d^-/-, FcRn^-/-, Flt3l^-/-, Foxn1^nu/n

SUBMITTER: Aranda F 

PROVIDER: S-EPMC6136857 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature