The adjuvant GLA-AF enhances human intradermal vaccine responses.

ABSTRACT: Adjuvants are key to shaping the immune response to vaccination, but to date, no adjuvant suitable for human use has been developed for intradermal vaccines. These vaccines could be self-administered and sent through the mail as they do not require long needles or technical expertise in immunization. In the event of a pandemic outbreak, this approach could alleviate the congregation of patients in health centers and thus reduce the potential of these centers to enhance the spread of lethal infection. A reliable and potent vaccine system for self-administration would provide an effective countermeasure for delivery through existing product distribution infrastructure. We report results from preclinical and clinical trials that demonstrate the feasibility of an adjuvanted, intradermal vaccin

SUBMITTER: Carter D 

PROVIDER: S-EPMC6136895 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature