Brain vascular intima vulnerability among HIV-positive and negative individuals.

ABSTRACT:

Objective

To test whether HIV is associated with brain large artery vulnerable intima.

Design

Cross-sectional study of autopsied HIV-positive (HIV+) cases sex and age-matched to HIV-negative (HIV-) controls.

Methods

Brain large arteries from 302 autopsied cases (50% HIV+) were evaluated morphometrically for the presence of atherosclerosis, size of necrotic core, and fibrous cap thickness. Intima vulnerability was measured as intima elastolytic score [0-5, based on intimal metalloproteinases (MMP)-2, MMP-3, and MMP-9, and tissue inhibitor for MMP-1 and MMP-2 staining], intima inflammatory score (0-3, based on intimal presence of CD3 and CD68 cells and TNF-α staining), neoangiogenesis (factor VIII staining), and apoptosis (caspase 3 staining). Hierarchical generalized l

SUBMITTER: Hunter MD 

PROVIDER: S-EPMC6136984 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature