Multicellular detachment generates metastatic spheroids during intra-abdominal dissemination in epithelial ovarian cancer.

ABSTRACT: Ovarian cancer is the most lethal gynecological cancer, where survival rates have had modest improvement over the last 30 years. Metastasis of cancer cells is a major clinical problem, and patient mortality occurs when ovarian cancer cells spread beyond the confinement of ovaries. Disseminated ovarian cancer cells typically spread within the abdomen, where ascites accumulation aids in their transit. Metastatic ascites contain multicellular spheroids, which promote chemo-resistance and recurrence. However, little is known about the origin and mechanisms through which spheroids arise. Using live-imaging of 3D culture models and animal models, we report that epithelial ovarian cancer (EOC) cells, the most common type of ovarian cancer, can spontaneously detach as either single cells or cluste

SUBMITTER: Al Habyan S 

PROVIDER: S-EPMC6137025 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature