Primaquine Pharmacokinetics in Lactating Women and Breastfed Infant Exposures.

ABSTRACT:

Background

Primaquine is the only drug providing radical cure of Plasmodium vivax malaria. It is not recommended for breastfeeding women as it causes hemolysis in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals, and breast milk excretion and thus infant exposure are not known.

Methods

Healthy G6PD-normal breastfeeding women with previous P. vivax infection and their healthy G6PD-normal infants between 28 days and 2 years old were enrolled. Mothers took primaquine 0.5 mg/kg/day for 14 days. Primaquine and carboxyprimaquine concentrations were measured in maternal venous plasma, capillary plasma, and breast milk samples and infant capillary plasma samples taken on days 0, 3, 7, and 13.

Results

In 20 mother-infant pairs, primaquine concentrations were belo

SUBMITTER: Gilder ME 

PROVIDER: S-EPMC6137118 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature