Fucosylated oligosaccharides in mother's milk alleviate the effects of caesarean birth on infant gut microbiota.

ABSTRACT: One of the most abundant components in human milk is formed by oligosaccharides, which are poorly digested by the infant. The oligosaccharide composition of breast milk varies between mothers, and is dependent on maternal secretor (FUT2) genotype. Secretor mothers produce milk containing α1-2 fucosylated human milk oligosaccharides, which are absent in the milk of non-secretor mothers. Several strains of bacteria in the infant gut have the capacity to utilise human milk oligosaccharides (HMOs). Here we investigate the differences in infant gut microbiota composition between secretor (N = 76) and non-secretor (N = 15) mothers, taking into account birth mode. In the vaginally born infants, maternal secretor status was not associated with microbiota composition. In the caesarean-born, however

SUBMITTER: Korpela K 

PROVIDER: S-EPMC6137148 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature