Geobiology reveals how human kidney stones dissolve in vivo.

ABSTRACT: More than 10% of the global human population is now afflicted with kidney stones, which are commonly associated with other significant health problems including diabetes, hypertension and obesity. Nearly 70% of these stones are primarily composed of calcium oxalate, a mineral previously assumed to be effectively insoluble within the kidney. This has limited currently available treatment options to painful passage and/or invasive surgical procedures. We analyze kidney stone thin sections with a combination of optical techniques, which include bright field, polarization, confocal and super-resolution nanometer-scale auto-fluorescence microscopy. Here we demonstrate using interdisciplinary geology and biology (geobiology) approaches that calcium oxalate stones undergo multiple events of disso

SUBMITTER: Sivaguru M 

PROVIDER: S-EPMC6137216 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature