Antibiotic prophylaxis for preventing endophthalmitis after intravitreal injection: a systematic review.

ABSTRACT:

Purpose

To assess the effect of topical antibiotic prophylaxis on the rate of post-operative endophthalmitis after intravitreal injection (IVI).

Methods

We conducted a systematic review of studies comparing the rates of endophthalmitis in eyes receiving IVI of different drugs with and without topical antibiotic prophylaxis, by searching MEDLINE and EMBASE up to June 2016. The methodological quality of the included studies was assessed using the Cochrane Risk of Bias tool and the Risk Of Bias in Non-randomized Studies of Interventions (ROBINS-I) for randomized clinical trials (RCTs) and non-randomized studies, respectively. We used a random-effects meta-analysis to compute the odds ratio (OR) of endophthalmitis with antibiotic prophylaxis compared with no prophylaxis and cond

SUBMITTER: Menchini F 

PROVIDER: S-EPMC6137222 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature