A regulatory circuitry comprising TP53, miR-29 family, and SETDB1 in non-small cell lung cancer.

ABSTRACT: Lung cancer is a malignant tumor with high fatality rate and causes great harm to human economic life. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. With the rapid development of epigenetic study in the last decade, the understanding of the pathogenesis of lung cancer and the development of personalized treatment of lung cancer are picking up pace. Previous studies showed that miR-29 family members (miR-29s; miR-29a, -29b, and -29c) are down-regulated in most human cancers, including NSCLC, but their biological roles in tumorigenesis and their regulation mechanism are still not fully elucidated. Herein, we reported that the miR-29a, -29b and, -29c were coincidently down-regulated in NSCLC, and the histone H3K9 methyltra

SUBMITTER: Chen B 

PROVIDER: S-EPMC6137244 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature