P58^IPK Is an Endogenous Neuroprotectant for Retinal Ganglion Cells.

ABSTRACT: p58^IPK is an endoplasmic reticulum (ER)-resident chaperone playing a critical role in facilitating protein folding and protein homeostasis. Previously, we have demonstrated that p58^IPK is expressed broadly in retinal neurons including retinal ganglion cells (RGCs) and loss of p58^IPK results in age-related RGC degeneration. In the present study, we investigate the role of p58^IPK in neuroprotection by in vitro and in vivo studies using primary RGC culture and two well-established disease-relevant RGC injury models: retinal ischemia/reperfusion (I/R) and microbead-induced ocular hypertension. Our results demonstrate that in both in vivo models, p58^{IPK -/-} mice exhibit significantly increased RGC loss compared to wild

SUBMITTER: McLaughlin T 

PROVIDER: S-EPMC6137320 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature