Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Whether vitamin D supplementation during pregnancy is beneficial and safe for offspring is unclear.

Objective

To systematically review studies of the effects of vitamin D supplementation during pregnancy on offspring growth, morbidity, and mortality.

Data sources

Searches of Medline, Embase, and the Cochrane Database of Systematic Reviews were conducted up to October 31, 2017. Key search terms were vitamin D, pregnancy, randomized controlled trials, and offspring outcomes.

Study selection

Randomized clinical trials of vitamin D supplementation during pregnancy and offspring outcomes.

Data extraction and synthesis

Two authors independently extracted data, and the quality of the studies was assessed. Summary risk ratio (RR), risk difference (RD)

SUBMITTER: Bi WG 

PROVIDER: S-EPMC6137512 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature