Estrogen receptor 1 gene polymorphisms are associated with metabolic syndrome in postmenopausal women in China.

ABSTRACT:

Background

Metabolic syndrome (MetS) includes obesity, diabetes, dyslipidemia and hypertension. Its incidence is rapidly increasing worldwide, particularly in postmenopausal women. Estrogens regulate glucose homeostasis and lipid metabolism via estrogen receptors 1 (ESR1) and 2 (ESR2). The current study aimed to elucidate associations of MetS with ESR1 and ESR2 gene polymorphisms in postmenopausal Chinese women.

Methods

This case-control study included 304 postmenopausal women (154 and 150 control and MetS patients, respectively). Clinical indicators related to MetS were assessed. Two ESR1 (PvuII and XbaI) and two ESR2 (RsaI and AluI) polymorphisms were evaluated by polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis.

Results

ESR1 polymor

SUBMITTER: Zhao L 

PROVIDER: S-EPMC6137943 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature