Ontology highlight
ABSTRACT:
SUBMITTER: Tuorto F
PROVIDER: S-EPMC6138434 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
The EMBO journal 20180809 18
Global protein translation as well as translation at the codon level can be regulated by tRNA modifications. In eukaryotes, levels of tRNA queuosinylation reflect the bioavailability of the precursor queuine, which is salvaged from the diet and gut microbiota. We show here that nutritionally determined Q-tRNA levels promote Dnmt2-mediated methylation of tRNA Asp and control translational speed of Q-decoded codons as well as at near-cognate codons. Deregulation of translation upon queuine depleti ...[more]