Ontology highlight
ABSTRACT:
SUBMITTER: Chen SH
PROVIDER: S-EPMC6138441 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
The EMBO journal 20180830 18
Multi-subunit cullin-RING ligases (CRLs) are the largest family of ubiquitin E3 ligases in humans. CRL activity is tightly regulated to prevent unintended substrate degradation or autocatalytic degradation of CRL subunits. Using a proteomics strategy, we discovered that CRL4<sup>AMBRA</sup><sup>1</sup> (CRL substrate receptor denoted in superscript) targets Elongin C (ELOC), the essential adapter protein of CRL5 complexes, for polyubiquitination and degradation. We showed that the ubiquitin liga ...[more]