Mycophenolic acid concentrations in peripheral blood mononuclear cells are associated with the incidence of rejection in renal transplant recipients.

ABSTRACT:

Aims

Although therapeutic drug monitoring of plasma mycophenolic acid (MPA) concentrations has been recommended to individualize dosage in transplant recipients, little is known regarding lymphocyte concentrations of MPA, where MPA inhibits inosine monophosphate dehydrogenase (IMPDH). This study investigated the utility of measuring predose MPA concentrations in peripheral blood mononuclear cells (C_0C ) and predose IMPDH activity, as predictors of graft rejection in renal transplant recipients.

Methods

Forty-eight patients commencing mycophenolate mofetil (1 g twice daily) in combination with tacrolimus and prednisolone were recruited. Blood was collected for determination of trough total (C_0P ) and unbound (C_0u ) plasma MPA concentrations. P

SUBMITTER: Md Dom ZI 

PROVIDER: S-EPMC6138476 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature