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In silico structure analysis and epitope prediction of E3 CR1-beta protein of Human Adenovirus E for vaccine design.

ABSTRACT: Human Adenoviruses are divided into 7 species of Human Adenovirus A to G based on DNA genome homology. The Human Adenovirus E (HAdVs-E) genome is a linear, double-stranded DNA containing 38 protein-coding genes. Wild-type adenoviruses type E, are linked to a number of slight illnesses. The most important part of HAdVs-E is E3 CR1-beta protein which controls the host immune response and viral attachment.We use numerous bio-informatics and immuno-informatics implements comprising sequence and construction tools for construction of 3D model and epitope prediction for HAdVs-E.The 3D structure of E3 CR1-beta protein was generated and total of ten antigenic B cell epitopes, 6 MHC class I and 11 MHC class II binding peptides were predicted.The study was carried out to predict antigenic determinants/epitopes of the E3 CR1-beta protein of Human Adenovirus E along with the 3D protein modeling. The study revealed potential T-cell and B-cell epitopes that can raise the desired immune response against E3 CR1-beta protein and useful in developing effective vaccines against HAdVs-E.

SUBMITTER: Patwary NI 

PROVIDER: S-EPMC6138513 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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In silico structure analysis and epitope prediction of E3 CR1-beta protein of Human Adenovirus E for vaccine design.

Patwary Noman Ibna Amin NI   Islam Md Saiful MS   Sohel Md M   Ara Ismot I   Sikder Mohd Omar Faruk MO   Shahik Shah Md SM  

Biomedical journal 20161227 6

<h4>Background</h4>Human Adenoviruses are divided into 7 species of Human Adenovirus A to G based on DNA genome homology. The Human Adenovirus E (HAdVs-E) genome is a linear, double-stranded DNA containing 38 protein-coding genes. Wild-type adenoviruses type E, are linked to a number of slight illnesses. The most important part of HAdVs-E is E3 CR1-beta protein which controls the host immune response and viral attachment.<h4>Method</h4>We use numerous bio-informatics and immuno-informatics imple  ...[more]