Major Depression Impairs the Use of Reward Values for Decision-Making.

ABSTRACT: Depression is a debilitating condition with a high prevalence. Depressed patients have been shown to be diminished in their ability to integrate their reinforcement history to adjust future behaviour during instrumental reward learning tasks. Here, we tested whether such impairments could also be observed in a Pavlovian conditioning task. We recruited and analysed 32 subjects, 15 with depression and 17 healthy controls, to study behavioural group differences in learning and decision-making. Participants had to estimate the probability of some fractal stimuli to be associated with a binary reward, based on a few passive observations. They then had to make a choice between one of the observed fractals and another target for which the reward probability was explicitly given. Computational mod

SUBMITTER: Rupprechter S 

PROVIDER: S-EPMC6138642 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature