Untargeted analysis of the airway proteomes of children with respiratory infections using mass spectrometry based proteomics.

ABSTRACT: The upper airway - which consists mainly of the naso- and oro-pharynx - is the first point of contact between the respiratory system and microbial organisms that are ubiquitous in the environment. It has evolved highly specialised functions to address these constant threats whilst facilitating seamless respiratory exchange with the lower respiratory tract. Dysregulation of its critical homeostatic and defence functions can lead to ingress of pathogens into the lower respiratory tract, potentially leading to serious illness. Systems-wide proteomic tools may facilitate a better understanding of mechanisms in the upper airways in health and disease. In this study, we aimed to develop a mass spectrometry based proteomics method for characterizing the upper airways proteome. Naso- and oropharyn

SUBMITTER: Sande CJ 

PROVIDER: S-EPMC6138648 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature