PD1^hi cells associate with clusters of proliferating B-cells in marginal zone lymphoma.

ABSTRACT:

Background

Abnormally sustained immune reactions drive B-cell proliferation in some cases of marginal zone lymphoma but the CD4⁺ T-cell subsets, which are likely to contribute to the B-cell responses in the tumour microenvironment, are not well characterised and neither has the spatial distribution of the different subsets in involved lymph nodes been investigated.

Methods

Employing a workflow of multiplex semi-automated immunohistochemistry combined with image processing we investigated association between infiltrating T-cells and proliferating lymphoma B-cells.

Results

Both total numbers of activating follicular helper (Tfh) cells (defined by high expression of PD1) and suppressive regulatory (Treg) T-cells (defined by FOXP3⁺ expression) and th

SUBMITTER: Wickenden K 

PROVIDER: S-EPMC6138907 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature