Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration.

ABSTRACT: The intestinal epithelium is largely maintained by self-renewing stem cells but with apparently committed progenitors also contributing, particularly following tissue damage. However, the mechanism of, and requirement for, progenitor plasticity in mediating pathological response remain unknown. Here we show that phosphorylation of the transcription factor Atoh1 is required for both the contribution of secretory progenitors to the stem cell pool and for a robust regenerative response. As confirmed by lineage tracing, Atoh1⁺ cells (Atoh1^(WT)CreERT2 mice) give rise to multilineage intestinal clones both in the steady state and after tissue damage. In a phosphomutant Atoh1^{(9S/T-A)CreERT2} line, preventing phosphorylation of ATOH1 protein acts to promote secretor

SUBMITTER: Tomic G 

PROVIDER: S-EPMC6138952 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature