Metabololipidomic profiling of functional immunoresolvent clusters and eicosanoids in mammalian tissues.

ABSTRACT: Metabolomics enables a systems approach to interrogate the bioactive mediators, their pathways and further metabolites involved in the physiology and pathophysiology of human and animal tissues. New metabololipidomic approaches with mass spectrometry presented in this brief review can now be utilized for the identification and profiling of lipid mediator networks that control inflammation-resolution in human blood and healthy and diseased solid tissues. Coagulation of blood is a protective response that prevents excessive bleeding on injury of blood vessels. Here, we review novel approaches to understand the relationship(s) between coagulation and resolution of inflammation and infection. To determine whether coagulation is involved in host-protective actions by lipid mediators, we used a

SUBMITTER: Norris PC 

PROVIDER: S-EPMC6139088 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature