Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants.

ABSTRACT:

Background

Neonatal hypoxic-ischemic encephalopathy (HIE) commonly leads to neurodevelopmental impairment, raising the need for prognostic tools which may guide future therapies in time. Prognostic value of proton MR spectroscopy (H-MRS) between 1 and 46 days of age has been extensively studied; however, the reproducibility and generalizability of these methods are controversial in a general clinical setting. Therefore, we investigated the prognostic performance of conventional H-MRS during first 96 postnatal hours in hypothermia-treated asphyxiated neonates.

Methods

Fifty-one consecutive hypothermia-treated HIE neonates were examined by H-MRS at three echo-times (TE = 35, 144, 288 ms) between 6 and 96 h of age, depending on clinical stability. Patients were divided into fav

SUBMITTER: Barta H 

PROVIDER: S-EPMC6139158 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature