Polymorphisms in the H19 gene and the risk of lung Cancer among female never smokers in Shenyang, China.

ABSTRACT:

Background

Long non-coding RNA (lncRNA) H19 is a hot spot in tumor development, progression and metastasis. This study assessed the association between H19 genetic polymorphisms and the susceptibility of lung cancer.

Methods

The case-control study was conducted to evaluate the association between four selected single nucleotide polymorphisms (rs217727, rs2107425, rs2735469 and rs17658052) in H19 gene and the risk of lung cancer. There were 556 female never smoking lung cancer patients and 395 cancer-free controls. Unconditional logistic regression analysis was used to analyze the associations between four SNPs and lung cancer risks by calculating the odds ratios and their 95% confidence intervals. The gene-environment interactions were assessed on both additive and multiplic

SUBMITTER: Yin Z 

PROVIDER: S-EPMC6139161 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature