CIRP increases ICAM-1⁺ phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis.

ABSTRACT: Sepsis represents uncontrolled inflammation due to an infection. Cold-inducible RNA-binding protein (CIRP) is a stress-induced damage-associated molecular pattern (DAMP). A subset of neutrophils expressing ICAM-1⁺ neutrophils was previously shown to produce high levels of reactive oxygen species. The role of CIRP for the development and function of ICAM-1⁺ neutrophils during sepsis is unknown. We hypothesize that CIRP induces ICAM-1 expression in neutrophils causing injury to the lungs during sepsis. Using a mouse model of cecal ligation and puncture (CLP)-induced sepsis, we found increased expression of CIRP and higher frequencies and numbers of ICAM-1⁺ neutrophils in the lungs. Conversely, the CIRP^-/- mice showed significant inhibition in the f

SUBMITTER: Ode Y 

PROVIDER: S-EPMC6139256 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature