Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia.

ABSTRACT:

Background

Epstein-Barr virus (EBV)-positive gastric cancers represent a distinct subtype of gastric cancers and account for nearly 10% of the gastric cancer burden, yet risk detection strategies for this cancer subtype are lacking.

Methods

We conducted a nested case-control study where we assayed 4 EBV antigens [viral capsid antigen (VCA), early antigen (EA), Epstein-Barr nuclear antigen (EBNA), and BZLF1-encoded replication activator protein (ZEBRA)] in either sera or plasma from 1447 gastric cancer cases and 1797 controls obtained from seven prospective cohorts representing individuals from the high gastric cancer-risk countries of China, Japan, and Korea.

Results

The prevalence of EBV sero-positivity was universal with the exception of one sero-negative individual

SUBMITTER: Varga MG 

PROVIDER: S-EPMC6139270 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature