Contraction of collecting lymphatics: organization of pressure-dependent rate for multiple lymphangions.

ABSTRACT: The paper describes the extension of a previously developed model of pressure-dependent contraction rate to the case of multiple lymphangions. Mechanical factors are key modulators of active lymphatic pumping. As part of the evolution of our lumped-parameter model to match experimental findings, we have designed an algorithm whereby the time until the next contraction depends on lymphangion transmural pressure in the contraction just completed. The functional dependence of frequency on pressure is quantitatively matched to isobaric contraction experiments on isolated lymphatic segments. When each of several lymphangions is given this ability, a scheme for their coordination must be instituted to match the observed synchronization. Accordingly, and in line with an experiment on an isolated

SUBMITTER: Bertram CD 

PROVIDER: S-EPMC6139274 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature