The CCHamide1 Neuropeptide Expressed in the Anterior Dorsal Neuron 1 Conveys a Circadian Signal to the Ventral Lateral Neurons in Drosophila melanogaster.

ABSTRACT: The fruit fly Drosophila melanogaster possesses approximately 150 brain clock neurons that control circadian behavioral rhythms. Even though individual clock neurons have self-sustaining oscillators, they interact and synchronize with each other through a network. However, little is known regarding the factors responsible for these network interactions. In this study, we investigated the role of CCHamide1 (CCHa1), a neuropeptide expressed in the anterior dorsal neuron 1 (DN_1a), in intercellular communication of the clock neurons. We observed that CCHa1 connects the DN_1a clock neurons to the ventral lateral clock neurons (LN_v) via the CCHa1 receptor, which is a homolog of the gastrin-releasing peptide receptor playing a role in circadian intercellular

SUBMITTER: Fujiwara Y 

PROVIDER: S-EPMC6139358 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature