Metabolic profiles derived from residual blood spot samples: A longitudinal analysis.

ABSTRACT: Background: Secondary use of newborn screening dried blood spot samples include use for biomedical or epidemiological research. However, the effects of storage conditions on archival samples requires further examination. The objective of this study was to determine the utility of residual newborn samples for deriving reliable metabolic gestational age estimates. Methods: Residual newborn dried blood spot samples that had been stored for 2-, 4-, 6-, or 12-months in temperature controlled (21°C) conditions were re-analyzed for the full panel of newborn screening analytes offered by a provincial newborn screening lab in Ottawa, Canada. Data from re-analyzed samples were compared to corresponding baseline newborn screening values for absolute agreement, and Pearson and intraclass

SUBMITTER: Murphy MSQ 

PROVIDER: S-EPMC6139383 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature