One-pot synthesis and biodistribution of fluorine-18 labeled serum albumin for vascular imaging.

ABSTRACT:

Introduction

Equilibrium single-photon radionuclide imaging methods for assessing cardiac function and the integrity of the vascular system have long been in use for both clinical and research purposes. However, positron-emitting blood pool agents that could provide PET equivalents to these (and other) clinical procedures have not yet been adopted despite technical imaging advantages offered by PET. Our goal was to develop a PET blood pool tracer that not only meets necessary in vivo biological requirements but can be produced with an uncomplicated and rapid synthesis method which would facilitate clinical translation. Herein, albumin labeled with fluorine-18 was synthesized using a one-pot method and evaluated in vitro and in vivo in rats.

Methods

A ligand (NODA-Bz-TFPE), c

SUBMITTER: Basuli F 

PROVIDER: S-EPMC6139435 | biostudies-literature | 2018 Jul - Aug

REPOSITORIES: biostudies-literature