Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle.

ABSTRACT: Skeletal muscle is the major site of postprandial peripheral glucose uptake, but in obesity-induced insulin-resistant states insulin-stimulated glucose disposal is markedly impaired. Despite the importance of skeletal muscle in regulating glucose homeostasis, the specific transcriptional changes associated with insulin-sensitive vs. -resistant states in muscle remain to be fully elucidated. Herein, using an RNA-seq approach we identified 20 genes differentially expressed in an insulin-resistant state in skeletal muscle, including cysteine- and glycine-rich protein 3 ( Csrp3), which was highly expressed in insulin-sensitive conditions but significantly reduced in the insulin-resistant state. CSRP3 has diverse functional roles including transcriptional regulation, signal transduction, and cy

SUBMITTER: Hernandez-Carretero A 

PROVIDER: S-EPMC6139493 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature