Compromised Activation of Vitamin D After Elective Surgery: A Prospective Pilot Study.

ABSTRACT: Surgical stress reduces concentrations of most proteins in serum and necessitates a rapid adjustment of hormones dependent on protein binding. Activation of vitamin D by renal 1α-hydroxylation is dependent on protein binding because 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) is formed after megalin-mediated reabsorption of 25-hydroxyvitamin D (25OHD) bound to vitamin D binding protein (DBP). Postoperative alterations in serum concentrations of DBP and albumin may therefore impair 1,25(OH)₂D₃ production. Our objective was to determine sex-specific changes in serum concentrations of vitamin D metabolites and sex steroids 2, 6, 24, and 48 hours and 3 weeks postoperatively. Fourteen women and eleven men aged 45 to 77 years without severe comorbidities und

SUBMITTER: Blomberg Jensen M 

PROVIDER: S-EPMC6139703 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature