Visual Temporal Contrast Sensitivity in the Behaving Mouse Shares Fundamental Properties with Human Psychophysics.

ABSTRACT: The mammalian visual system has a remarkable capacity to detect differences in contrast across time, which is known as temporal contrast sensitivity (TCS). Details of the underlying neural mechanisms are rapidly emerging as a result of a series of elegant electrophysiological studies performed largely with the mouse as an experimental model. However, rigorous psychophysical methods are necessary to pair the electrophysiology with temporal visual behavior in mouse. The optomotor response is frequently used as a proxy for retinal temporal processing in rodents. However, subcortical reflexive pathways drive the optomotor response rather than cortical decision-making areas. To address this problem, we have developed an operant behavior assay that measures TCS in behaving mice. Mice were traine

SUBMITTER: Umino Y 

PROVIDER: S-EPMC6140104 | biostudies-literature | 2018 Jul-Aug

REPOSITORIES: biostudies-literature