Cytokines profile of reverse cardiac remodeling following transcatheter aortic valve replacement.

ABSTRACT:

Objective

Previous studies have suggested that cytokines and growth factors may predict ventricular recovery following aortic valve replacement (AVR). The primary objective of this study was to identify cytokines that predict ventricular recovery following transcatheter AVR (TAVR).

Methods

We prospectively enrolled 121 consecutive patients who underwent TAVR. Standard echocardiographic assessment at baseline, 1-month and 1-year after TAVR included left ventricular (LV) mass index (LVMI) and global longitudinal strain (GLS). Blood samples were obtained at the time of the procedure to measure cytokines using a 63-plex Luminex platform. Partial least squares-discriminant analysis was performed to identify cytokines associated with ventricular remodeling and function at baseline

SUBMITTER: Kim JB 

PROVIDER: S-EPMC6140353 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature