Size and topology modulate the effects of frustration in protein folding.

ABSTRACT: The presence of conflicting interactions, or frustration, determines how fast biomolecules can explore their configurational landscapes. Recent experiments have provided cases of systems with slow reconfiguration dynamics, perhaps arising from frustration. While it is well known that protein folding speed and mechanism are strongly affected by the protein native structure, it is still unknown how the response to frustration is modulated by the protein topology. We explore the effects of nonnative interactions in the reconfigurational and folding dynamics of proteins with different sizes and topologies. We find that structural correlations related to the folded state size and topology play an important role in determining the folding kinetics of proteins that otherwise have the same amount

SUBMITTER: Kluber A 

PROVIDER: S-EPMC6140544 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature