Spillage of bacterial products during colon surgery increases the risk of liver metastases development in a rat colon carcinoma model.

ABSTRACT: Surgical resection of the primary tumor provides the best chance of cure for patients with colorectal carcinoma (CRC). However, bacterial translocation during intestinal surgery has been correlated with poor long-term oncological outcome. Therefore, we investigated the influence of bacterial contamination during colon surgery on CRC liver metastases development. Blood and liver samples of patients undergoing resection of primary CRC or liver metastases were collected. Cell numbers, activation markers and inflammatory mediators were determined. Tumor cell adhesion and outgrowth after sham- or colectomy operations were determined in a rat model, in which tumor cells had been injected into the portal vein. White blood cells and granulocytes were increased in per- and post-operative patient bl

SUBMITTER: Grewal S 

PROVIDER: S-EPMC6140552 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature