The Effect of Increasing Dialysate Magnesium on Serum Calcification Propensity in Subjects with End Stage Kidney Disease: A Randomized, Controlled Clinical Trial.

ABSTRACT:

Background and objectives

Serum calcification propensity is a novel functional test that quantifies the functionality of the humeral system of calcification control. Serum calcification propensity is measured by T₅₀, the time taken to convert from primary to secondary calciprotein particle in the serum. Lower T₅₀ represents higher calcification propensity and is associated with higher risk of cardiovascular events and death in patients with ESKD. Increasing magnesium in serum increases T₅₀, but so far, no clinical trials have investigated whether increasing serum magnesium increases serum calcification propensity in subjects with ESKD.

Design, setting, participants, & measurements

We conducted a single-center, randomized, double-blinded, para

SUBMITTER: Bressendorff I 

PROVIDER: S-EPMC6140556 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature