Characteristics of Colon-Derived Uremic Solutes.

ABSTRACT:

Background and objectives

Colon microbial metabolism produces solutes that are normally excreted in the urine and accumulate in the plasma when the kidneys fail. This study sought to further identify and characterize human colon-derived uremic solutes.

Design, setting, participants, & measurements

Colon-derived solutes normally excreted in the urine were identified by comparing urine from controls (n=17) and patients with total colectomies (n=12), using an established metabolomic platform. Colon-derived solutes that accumulate in kidney failure were then identified by comparing the plasma of the control patients with that of patients on dialysis (n=14).

Results

Ninety-one urinary solutes were classified as colon-derived on the basis of the finding

SUBMITTER: Mair RD 

PROVIDER: S-EPMC6140561 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature