IgA Nephropathy Susceptibility Loci and Disease Progression.

ABSTRACT:

Background and objectives

At least 20 susceptibility loci of IgA nephropathy have been identified by genome-wide association studies to date. Whether these loci were associated with disease progression is unclear.

Design, setting, participants, & measurements

We enrolled 613 adult patients with IgA nephropathy for a follow-up of ≥12 months. All 20 IgA nephropathy susceptibility loci were selected and their tag single nucleotide polymorphisms (SNPs) were genotyped. After strict quality control, 16 SNPs and 517 patients with IgA nephropathy were eligible for subsequent analysis. Progression was defined as ESKD or 50% decrease in eGFR. A stepwise Cox regression analysis of all SNPs on Akaike information criterion was performed to select the best model.

Results

A four-SNP

SUBMITTER: Shi M 

PROVIDER: S-EPMC6140573 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature