Establishment and validation of a 7-microRNA prognostic signature for non-small cell lung cancer.

ABSTRACT:

Purpose

A series of microRNAs (miRNAs) have been identified as associated with the survival of patients with non-small-cell lung cancer (NSCLC). The aim of the present study was to explore whether combination of these experimentally validated individual miRNA biomarkers could be used to further increase their prognostic power in NSCLC.

Patients and methods

Based on previously validated NSCLC prognostic miRNAs, gene signatures that could discriminate high-risk subgroups with poor clinical outcome in four NSCLC miRNA expression datasets (GSE13937, GSE16025, The Cancer Genome Atlas Lung Adenocarcinoma, and TCGA lung squamous cell carcinoma) were developed using the SurvMicro tool. The potential of the miRNA signature established was validated by quantitative real-time PCR analy

SUBMITTER: Wang N 

PROVIDER: S-EPMC6140736 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature