DNMT1 modulates interneuron morphology by regulating Pak6 expression through crosstalk with histone modifications.

ABSTRACT: Epigenetic mechanisms of gene regulation, including DNA methylation and histone modifications, call increasing attention in the context of development and human health. Thereby, interactions between DNA methylating enzymes and histone modifications tremendously multiply the spectrum of potential regulatory functions. Epigenetic networks are critically involved in the establishment and functionality of neuronal circuits that are composed of gamma-aminobutyric acid (GABA)-positive inhibitory interneurons and excitatory principal neurons in the cerebral cortex. We recently reported a crucial role of the DNA methyltransferase 1 (DNMT1) during the migration of immature POA-derived cortical interneurons by promoting the migratory morphology through repression of Pak6. However, the DNMT1-dependen

SUBMITTER: Symmank J 

PROVIDER: S-EPMC6140805 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature