Loci-specific histone acetylation profiles associated with transcriptional coactivator p300 during early myoblast differentiation.

ABSTRACT: Molecular regulation of stem cell differentiation is exerted through both genetic and epigenetic determinants over distal regulatory or enhancer regions. Understanding the mechanistic action of active or poised enhancers is therefore imperative for control of stem cell differentiation. Based on the genome-wide co-occurrence of different epigenetic marks in committed proliferating myoblasts, we have previously generated a 14-state chromatin state model to profile rexinoid-responsive histone acetylation in early myoblast differentiation. Here, we delineate the functional mode of transcription regulators during early myogenic differentiation using genome-wide chromatin state association. We define a role of transcriptional coactivator p300, when recruited by muscle master regulator MyoD, in t

SUBMITTER: Khilji S 

PROVIDER: S-EPMC6140897 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature