Liver transcriptomic and plasma metabolomic profiles of fattening lambs are modified by feed restriction during the suckling period.

ABSTRACT: The increasing world population is driving demand for improved efficiency of feed resources of livestock. However, the molecular mechanisms behind various feed efficiency traits and their regulation by nutrition remain poorly understood. Here, we aimed to identify differentially expressed (DE) genes in the liver tissues of fattening Merino lambs and differences in metabolites accumulated in plasma to identify modified metabolic pathways as a consequence of milk restriction during the suckling period. Twenty-four male Merino lambs (4.81 ± 0.256 kg) were divided into 2 groups (n = 12 per dietary treatment). The first group (ad libitum, ADL) was kept permanently with the dams, whereas the other group (restricted, RES) was milk restricted. When they reached 15 kg of live body weight (LBW), all

SUBMITTER: Santos A 

PROVIDER: S-EPMC6140908 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature