Chronic social stress induces DNA methylation changes at an evolutionary conserved intergenic region in chromosome X.

ABSTRACT: Chronic stress resulting from prolonged exposure to negative life events increases the risk of mood and anxiety disorders. Although chronic stress can change gene expression relevant for behavior, molecular regulators of this change have not been fully determined. One process that could play a role is DNA methylation, an epigenetic process whereby a methyl group is added onto nucleotides, predominantly cytosine in the CpG context, and which can be induced by chronic stress. It is unknown to what extent chronic social defeat, a model of human social stress, influences DNA methylation patterns across the genome. Our study addressed this question by using a targeted-capture approach called Methyl-Seq to investigate DNA methylation patterns of the dentate gyrus at putative regulatory regions a

SUBMITTER: Hing B 

PROVIDER: S-EPMC6140912 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature