T-Bet⁺ IgM Memory Cells Generate Multi-lineage Effector B Cells.

ABSTRACT: Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-labeled CD11c⁺ and CD11c^neg T-bet⁺ IgM memory cells after their transfer into naive recipient mice. Following challenge infection, many memory cells differentiated into IgM-producing plasmablasts. Other donor B cells entered germinal centers, downregulated CD11c, underwent class switch recombination, and became switched memory cells. Yet other donor cells were maintained as IgM memory cells, and these IgM memory cells retained their multi-lineage potential following serial transfer. These findings were corrobo

SUBMITTER: Kenderes KJ 

PROVIDER: S-EPMC6141031 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature