Association of tooth loss with liver cancer incidence and chronic liver disease mortality in a rural Chinese population.

ABSTRACT:

Background

Tooth loss has been reported to be associated with the risk of liver cancer in several prior studies in economically advantaged countries. Whether this relationship is also evident in economically disadvantaged populations is not known.

Methods

We analyzed data from the Nutrition Intervention Trials, two randomized placebo-controlled trials of vitamin/mineral supplementation in Linxian, China. Participants who reported having lost permanent teeth were examined to determine the number of teeth remaining. In the 30-year follow-up period, 329 liver cancers were diagnosed and 368 chronic liver disease deaths occurred. Tooth loss was categorized based on loess smoothed age-specific predicted quartiles. Cox proportional hazards regression was used to estimate hazard rat

SUBMITTER: Thistle JE 

PROVIDER: S-EPMC6141082 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature