Clinico-pathological significance of exosome marker CD63 expression on cancer cells and stromal cells in gastric cancer.

ABSTRACT:

Background

It has been reported that CD63, an exosome marker, is expressed in solid cancer tissues. However, its significance in patients with gastric cancer has not been clarified. Exosomes derived from cancer cells and stromal cells might play an important role in the intracellular communications involved in the development of carcinoma. This study aimed to clarify the relationship between CD63 expression in cancer cells and stromal cells and clinical-pathologic factors.

Methods

A total of 595 gastric cancer patients were enrolled in this study. CD63 expression in cancer cells and stromal cells was analyzed by immunohistochemistry. The correlations between CD63 expression and several clinicopathological factors were investigated.

Results

CD63 expression was mainly o

SUBMITTER: Miki Y 

PROVIDER: S-EPMC6141093 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature