Podoplanin-positive cancer-associated fibroblasts predict poor prognosis in lung cancer patients.

ABSTRACT:

Background

Cancer-associated fibroblasts (CAFs) are a heterogeneous population, and different subpopulations play differential roles in tumor microenvironment. However, the prognostic role of podoplanin-positive CAFs in human lung cancer still remains controversial.

Methods

Herein, we performed a meta-analysis including 12 published studies with 1,802 patients identified from PubMed and EBSCO to assess the prognostic impact of podoplanin-positive CAFs in lung cancer patients.

Results

We found that podoplanin⁺ fibroblast infiltration significantly decreased overall survival (OS), disease-free survival (DFS), and progression-free survival in patients. In stratified analyses, podoplanin⁺ fibroblast infiltration was significantly associated with wors

SUBMITTER: Hu G 

PROVIDER: S-EPMC6141120 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature