Renal tubule insulin receptor modestly promotes elevated blood pressure and markedly stimulates glucose reabsorption.

ABSTRACT: Although the cause of hypertension among individuals with obesity and insulin resistance is unknown, increased plasma insulin, acting in the kidney to increase sodium reabsorption, has been proposed as a potential mechanism. Insulin may also stimulate glucose uptake, but the contributions of tubular insulin signaling to sodium or glucose transport in the setting of insulin resistance is unknown. To directly study the role of insulin signaling in the kidney, we generated inducible renal tubule-specific insulin receptor-KO mice and used high-fat feeding and mineralocorticoids to model obesity and insulin resistance. Insulin receptor deletion did not alter blood pressure or sodium excretion in mice on a high-fat diet alone, but it mildly attenuated the increase in blood pressure with mineralo

SUBMITTER: Nizar JM 

PROVIDER: S-EPMC6141164 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature