Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells.

ABSTRACT: Following CNS demyelination, oligodendrocyte progenitor cells (OPCs) are able to differentiate into either remyelinating oligodendrocytes (OLs) or remyelinating Schwann cells (SCs). However, the signals that determine which type of remyelinating cell is generated and the underlying mechanisms involved have not been identified. Here, we show that distinctive microenvironments created in discrete niches within demyelinated white matter determine fate decisions of adult OPCs. By comparative transcriptome profiling we demonstrate that an ectopic, injury-induced perivascular niche is enriched with secreted ligands of the BMP and Wnt signalling pathways, produced by activated OPCs and endothelium, whereas reactive astrocyte within non-vascular area express the dual BMP/Wnt antagonist Sostdc1. Th

SUBMITTER: Ulanska-Poutanen J 

PROVIDER: S-EPMC6141235 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature